Andrew attended the University of Iowa from 2004-2008, where he received degrees in Biochemistry and Mathematics. He did his PhD in Molecular Biophysics with the Craig Townsend lab at The Johns Hopkins University. Andrew's thesis work encompassed X-ray crystallography and enzyme kinetics and he worked to uncover a previously hidden set of rules that dictate the structure-function relationships of Ser, Cys, and Thr hydrolases. In 2013, Andrew started his postdoctoral fellowship in Frances Arnold's lab at the California Institute of Technology. There, Andrew applied directed evolution to produce the first new generation of non-canonical amino acids synthases.

In 2017, Andrew started his independent career as an Assistant Professor in the Department of Chemistry at the University of Wisconsin Madison. The Buller group has three areas of focus: principles of PLP enzyme catalysis, the chemistry of cobalt-protoporphyrin hemoproteins, and developing practical engineering methodologies to increase the efficiency of directed evolution. Details of the group's work are highlighted on the Research page. Our work has been recognized with an NIH New Innovator Award, NIH MIRA Awards, NSF CAREER fellowship, Romnes Faculty Fellowship, and an Alfred P Sloan Foundation Fellowship. 

In 2026, the Buller group relocated to the Manchester Institute of Biotechnology in association with the Department of Chemistry at the University of Manchester. We are pursuing our interests at the intersection of detailed mechanistic enzymology and practical biocatalysis. If you want to join our team, please see the Contact page for further information. 

Outside of science, Andrew enjoys spending time with his family. Having grown up in the US, we are loving getting to explore the beautiful and friendly city of Manchester, the United Kingdom, and the rest of Europe. Andrew is an avid reader of SciFi-Fantasy, table top gaming, and solo sports such as swimming and running.